Vol. 17, No. 2, Apr 2026

Published: 2026-03-05

Review

Advances in Targeted Therapy for Human Epidermal Growth Factor Receptor 2-Low Tumors: From Trastuzumab to Antibody-Drug Conjugates

Zhi Nuo Zheng, Xiao Han Shen, Xiao Ban Ye, Tao Li, Jie Guo

129-142
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DOI: https://doi.org/10.14740/wjon2718

Original Article

TP53 Loss Fuels mTORC1 Activation and Autophagy Suppression to Drive Immune-Cold Colorectal Cancer

Eunseuk Lee, Dana Al-Assi, Randy Rivera-Rueda, Sharon Susan Paul, Aksa Joy

143-156
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DOI: https://doi.org/10.14740/wjon2695
Analysis of Prognosis and Immune Microenvironment of Protein Kinase C Substrate 80K-H in Diabetic Lung Cancer Patients

Xiang Ying Li, Yue Feng, Cun Feng Li, Hong Qiao

157-177
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DOI: https://doi.org/10.14740/wjon2663
Characterization of Acute Myeloid Leukemia With t(16;21) Translocation: Cytogenetic, Molecular, and Immunophenotypic Findings

Milder Bravo-Davila, Dayana Espinoza-Rodrigez, Javier Orejon-Huarancca, Richard Junior Zapata Dongo

178-190
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DOI: https://doi.org/10.14740/wjon2700
Identification of Genes and Construction of Prognostic Model of Lung Adenocarcinoma Based on Propionate Metabolism-Related Genes

Min Min Li, Wei Jia Fu, Ying Zhou, Huan Huan Zhang, Hai Ning Li, Chu Zhang, Jin Yang

191-208
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DOI: https://doi.org/10.14740/wjon2680
Expression of Bruton’s Tyrosine Kinase Reflects Immune Cells Infiltration and Cell Proliferation in Breast Cancer

Tamrah AlRammah, Rongrong Wu, Kohei Chida, Kei Kawashima, Kenichi Hakamada, Takashi Ishikawa, John M.L. Ebos, Kazuaki Takabe

209-222
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DOI: https://doi.org/10.14740/wjon2708
Strong Signals of Adverse Events in Tyrosine Kinase Inhibitor Therapy for Liver Cancer Treatment

Wen Xuan Zhou, Jun Hao Fan, Qian Wen Ni, Ming Kai Liu, Zhen Peng, Yuan Xu, Su Su Luo

223-236
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DOI: https://doi.org/10.14740/wjon2685
Functional and Survival Outcomes of Partial Versus Radical Nephrectomy in Renal Cell Carcinoma Patients With Pre-Existing Chronic Kidney Disease: A Real-World Study

Luan Kinh Thai, Viet Quang Luu, Sam Minh Thai

237-246
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DOI: https://doi.org/10.14740/wjon2728
Multi-Omics and Single-Cell Mendelian Randomization Reveal a Potential Role of VNN2 in Lung Adenocarcinoma in Resting Natural Killer Cells

Zhi Chun Xue, Jing Lin, Jian Hui Wu, Zhi Wen Peng, Mei Yan Tang, Peng Liang, Hui Ling Chen, Gui Ju Fang, Qing Xue

247-255
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DOI: https://doi.org/10.14740/wjon2689
Bidirectional Mendelian Randomization Analysis Reveals Causal Associations Between Autoimmune Diseases and Colorectal Cancer

Shuang Liu, Kun Chen, Yue Qi Wang, Xiao Yu Gupta, Zhi He, Chen Zhang, Guo Qiu Wu, Su Su Luo, Xing Jin

256-267
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DOI: https://doi.org/10.14740/wjon2732
Clinical Outcomes and Prognostic Factors in Metastatic Triple-Negative Breast Cancer: A Real-World Data Analysis

Moe Itakura, Yoshiya Horimoto, Yumiko Ushiyama, Yuko Ueki, Yumiko Ishizuka, Yoichi Koyama, Kyoko Orimoto, Hiroki Kusama, Takahiko Kawate, Takashi Ishikawa, Junichiro Watanabe, Goro Kutomi

268-276
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DOI: https://doi.org/10.14740/wjon2713