World J Oncol

World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access

Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc

Journal website https://wjon.elmerpub.com

Original Article

Volume 000, Number 000, July 2026, pages 000-000

Chemoradiotherapy Is Associated With Improved Overall Survival in Intestinal-Type Gastric Cancer: A Retrospective Analysis

↓ Figure 2. The incidence rate and the number of patients with intestinal GC by year, gender, and race (a, c, e: incidence rate per 100,000; b, d, f: number). GC: gastric cancer.

↓ Figure 3. Kaplan–Meier curves of patients with intestinal GC by age during three decades. GC: gastric cancer.

↓ Figure 4. The overall trend of Kaplan–Meier curves of patients with intestinal GC during three decades (a), and the survival trends by sex (b), race (c), and stage (d). GC: gastric cancer.

↓ Figure 5. The survival of patients with chemotherapy and radiotherapy. (a, c, e, g) Survival effect of radiotherapy by the decision to accept radiotherapy, stage, age, and year. (b, d, f, h) Survival effect of chemotherapy by the decision to receive chemotherapy, stage, age, and year.

↓ Figure 6. The survival of patients with chemoradiotherapy by the decision to accept chemoradiotherapy, sex, race, stage, and age.

↓ Figure 7. Multivariate analysis of the independent risk factors that influence the survival of patients with intestinal GC by radiotherapy (a), chemotherapy (b), and chemoradiotherapy (c).

↓ **Table 1.** Characteristics of Patients With Intestinal-Type GC
Characteristics	N = 4,295	Percentage (%)
GC: gastric cancer.
Sex
Male	2,292	53.3
Female	1,193	27.8
Unknown	810	18.9
Race
White	1,613	37.6
Black	426	9.9
Other	1,436	33.4
Unknown	820	19.1
Age
< 60	553	12.9
≥ 60	2,922	68.0
Unknown	820	19.1
Stage
Distant	820	19.1
Localized	1,084	25.2
Regional	1,320	30.7
Unknown	1,071	25.0
Chemotherapy
Yes	1,490	34.7
No/unknown	2,805	65.3
Radiotherapy
Yes	868	20.2
Refuse	42	1.0
Unknown	3,368	78.8

↓ Table 1. Characteristics of Patients With Intestinal-Type GC

Characteristics

N = 4,295

Percentage (%)

GC: gastric cancer.

Sex

Male

2,292

53.3

Female

1,193

27.8

Unknown

810

18.9

Race

White

1,613

37.6

Black

426

9.9

Other

1,436

33.4

Unknown

820

19.1

Age

< 60

553

12.9

≥ 60

2,922

68.0

Unknown

820

19.1

Stage

Distant

820

19.1

Localized

1,084

25.2

Regional

1,320

30.7

Unknown

1,071

25.0

Chemotherapy

Yes

1,490

34.7

No/unknown

2,805

65.3

Radiotherapy

Yes

868

20.2

Refuse

1.0

Unknown

3,368

78.8

↓ **Table 2.** The Incidence of Intestinal-Type Gastric Cancer According to Age Group and Decade Within Sex and Race Groups From 1988 to 2017 at the Nine Original SEER Sites
Variable	Age group	Year at diagnose
Data are incidence per 100,000 people by year of diagnosis, with the number of patients in parentheses.
Total	0–85+	0.29 (852)	0.48 (1,591)	0.49 (1,852)
	0–49	0.01 (28)	0.03 (70)	0.04 (79)
	50–59	0.27 (65)	0.4 (148)	0.49 (223)
	60–69	0.95 (196)	1.19 (277)	1.18 (417)
	70+	2.36 (563)	3.76 (1,096)	3.14 (1,133)
Sex
Male	0–85+	0.43 (603)	0.62 (1,016)	0.64 (1,224)
	0–49	0.02 (23)	0.05 (53)	0.05 (57)
	50–59	0.5 (56)	0.63 (109)	0.73 (160)
	60–69	1.55 (148)	1.74 (188)	1.84 (315)
	70+	4.03 (376)	5.59 (666)	4.36 (692)
Female	0–85+	0.17 (249)	0.34 (575)	0.34 (628)
	0–49	0 (5)	0.02 (17)	0.02 (22)
	50–59	0.05 (9)	0.19 (39)	0.25 (63)
	60–69	0.43 (48)	0.7 (89)	0.58 (102)
	70+	1.31 (187)	2.54 (430)	2.25 (441)
Race
White	0–85+	0.13 (313)	0.3 (768)	0.34 (941)
	0–49	0.01 (13)	0.02 (35)	0.03 (47)
	50–59	0.13 (27)	0.25 (76)	0.31 (111)
	60–69	0.38 (65)	0.66 (123)	0.76 (214)
	70–79	0.98 (208)	2.19 (534)	1.94 (569)
Black	0–85+	0.23 (69)	0.44 (197)	0.55 (290)
	0–49	0.01 (3)	0.04 (14)	0.05 (14)
	50–59	0.41 (8)	0.79 (28)	0.82 (42)
	60–69	1.70 (27)	2.04 (48)	2.51 (93)
	70+	2.04 (31)	4.73 (107)	4.33 (141)
Other	0–85+	1.75 (470)	1.64 (626)	1.23 (621)
	0–49	0.06 (12)	0.09 (21)	0.06 (18)
	50–59	1.45 (30)	1.16 (44)	1.28 (70)
	60–69	5.78 (104)	4.47 (106)	2.85 (110)
	70–79	20.5 (324)	17.26 (455)	10.61 (423)

↓ Table 2. The Incidence of Intestinal-Type Gastric Cancer According to Age Group and Decade Within Sex and Race Groups From 1988 to 2017 at the Nine Original SEER Sites

Variable

Age group

Year at diagnose

1988–1997

1998–2007

2008–2017

Data are incidence per 100,000 people by year of diagnosis, with the number of patients in parentheses.

Total

0–85+

0.29 (852)

0.48 (1,591)

0.49 (1,852)

0–49

0.01 (28)

0.03 (70)

0.04 (79)

50–59

0.27 (65)

0.4 (148)

0.49 (223)

60–69

0.95 (196)

1.19 (277)

1.18 (417)

70+

2.36 (563)

3.76 (1,096)

3.14 (1,133)

Sex

Male

0–85+

0.43 (603)

0.62 (1,016)

0.64 (1,224)

0–49

0.02 (23)

0.05 (53)

0.05 (57)

50–59

0.5 (56)

0.63 (109)

0.73 (160)

60–69

1.55 (148)

1.74 (188)

1.84 (315)

70+

4.03 (376)

5.59 (666)

4.36 (692)

Female

0–85+

0.17 (249)

0.34 (575)

0.34 (628)

0–49

0 (5)

0.02 (17)

0.02 (22)

50–59

0.05 (9)

0.19 (39)

0.25 (63)

60–69

0.43 (48)

0.7 (89)

0.58 (102)

70+

1.31 (187)

2.54 (430)

2.25 (441)

Race

White

0–85+

0.13 (313)

0.3 (768)

0.34 (941)

0–49

0.01 (13)

0.02 (35)

0.03 (47)

50–59

0.13 (27)

0.25 (76)

0.31 (111)

60–69

0.38 (65)

0.66 (123)

0.76 (214)

70–79

0.98 (208)

2.19 (534)

1.94 (569)

Black

0–85+

0.23 (69)

0.44 (197)

0.55 (290)

0–49

0.01 (3)

0.04 (14)

0.05 (14)

50–59

0.41 (8)

0.79 (28)

0.82 (42)

60–69

1.70 (27)

2.04 (48)

2.51 (93)

70+

2.04 (31)

4.73 (107)

4.33 (141)

Other

0–85+

1.75 (470)

1.64 (626)

1.23 (621)

0–49

0.06 (12)

0.09 (21)

0.06 (18)

50–59

1.45 (30)

1.16 (44)

1.28 (70)

60–69

5.78 (104)

4.47 (106)

2.85 (110)

70–79

20.5 (324)

17.26 (455)

10.61 (423)

↓ **Table 3.** Univariate Analysis of Radiotherapy on Overall Survival
Subtype	HR (95% CI)	^P
CI: confidence interval; HR: hazard ratio.
Sex
Female	1
Male	1.067 (0.8989–1.269)	0.4614
Radiotherapy
Accept	1
Refuse	1.368 (0.9690–2. 173)	0.0051
Age
< 65	1
≥ 65	1.218 (1.036–1.428)	0.0124
Stage
Distant	1
Localized	0.266 (0.197–0.358)	< 0.0001
Regional	0.269 (0.217–0.332)	< 0.0001
Race
White	1
Black	0.9865 (0.7646–1.272)	0.9155
Other	1.001 (0.8482–1. 182)	0.9895

↓ Table 3. Univariate Analysis of Radiotherapy on Overall Survival

Subtype

HR (95% CI)

CI: confidence interval; HR: hazard ratio.

Sex

Female

Male

1.067 (0.8989–1.269)

0.4614

Radiotherapy

Refuse

1.368 (0.9690–2. 173)

0.0051

Age

< 65

≥ 65

1.218 (1.036–1.428)

0.0124

Stage

Distant

Localized

0.266 (0.197–0.358)

< 0.0001

Regional

0.269 (0.217–0.332)

< 0.0001

Race

White

Black

0.9865 (0.7646–1.272)

0.9155

Other

1.001 (0.8482–1. 182)

0.9895

↓ **Table 4.** Univariate Analysis of Chemotherapy on Overall Survival
Subtype	HR (95% CI)	P
CI: confidence interval; HR: hazard ratio.
Sex
Female	1
Male	1.127 (0.9873–1.287)	0.0809
Chemotherapy
Accept	1
No/known	1.380 (1.281–1.480)	< 0.0001
Age
< 65	1
≥ 65	1.215 (1.077–1.378)	0.0020
Stage
Distant	1
Localized	0.232 (0.183–0.294)	< 0.0001
Regional	0.305 (0.264–0.352)	< 0.0001
Race
White	1
Black	1.026 (0.8453–1.247)	0.7928
Other	1.020 (0.8951–1. 164)	0.7638

↓ Table 4. Univariate Analysis of Chemotherapy on Overall Survival

Subtype

HR (95% CI)

CI: confidence interval; HR: hazard ratio.

Sex

Female

Male

1.127 (0.9873–1.287)

0.0809

Chemotherapy

No/known

1.380 (1.281–1.480)

< 0.0001

Age

< 65

≥ 65

1.215 (1.077–1.378)

0.0020

Stage

Distant

Localized

0.232 (0.183–0.294)

< 0.0001

Regional

0.305 (0.264–0.352)

< 0.0001

Race

White

Black

1.026 (0.8453–1.247)

0.7928

Other

1.020 (0.8951–1. 164)

0.7638

↓ **Table 5.** Univariate Analysis of Chemoradiotherapy on Overall Survival
Subtype	HR (95% CI)	P
CI: confidence interval; HR: hazard ratio.
Sex
Female	1
Male	1.299 (1.061–1.564)	0.0117
Chemoradiotherapy
Accept	1
No/known	1.279 (1.164–1.424)	< 0.0001
Age
< 65	1
≥ 65	1.219 (0.9610–1.545)	0.1063
Stage
Distant	1
Localized	0.278 (0.196–0.394)	< 0.0001
Regional	0.326 (0.257–0.416)	< 0.0001
Race
White	1
Black	1.122 (0.829–1.518)	0.455
Other	0.957 (0.777–1. 179)	0.680

↓ Table 5. Univariate Analysis of Chemoradiotherapy on Overall Survival

Subtype

HR (95% CI)

CI: confidence interval; HR: hazard ratio.

Sex

Female

Male

1.299 (1.061–1.564)

0.0117

Chemoradiotherapy

No/known

1.279 (1.164–1.424)

< 0.0001

Age

< 65

≥ 65

1.219 (0.9610–1.545)

0.1063

Stage

Distant

Localized

0.278 (0.196–0.394)

< 0.0001

Regional

0.326 (0.257–0.416)

< 0.0001

Race

White

Black

1.122 (0.829–1.518)

0.455

Other

0.957 (0.777–1. 179)

0.680