World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access
Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc
Journal website https://wjon.elmerpub.com

Original Article

Volume 17, Number 1, February 2026, pages 95-105

A Comparison of Five-Year Survival Rates Between Thermal Ablation and Hepatic Resection for Colorectal Cancer Metastasis to the Liver: A Systematic Review and Meta-Analysis

Figures

↓  Figure 1. PRISMA chart.
Figure 1.
↓  Figure 2. Five-year overall survival.
Figure 2.
↓  Figure 3. Tumor recurrence.
Figure 3.
↓  Figure 4. Disease-free survival.
Figure 4.
↓  Figure 5. Complication rate.
Figure 5.
↓  Figure 6. Meta-regression bubble plot.
Figure 6.

Tables

↓  Table 1. Study and Participant Characteristics
 
Author Year Design Location Sample size Age (mean) Males/females Tumor size (mean, cm) Follow-up (mean, months)
Vogl et al [9] 2014 Retrospective Germany 594 61.2 406:188 3.4 22.5
Chiappa et al [10] 2016 Retrospective Italy 360 59 168:192 2.7 90.3
Dijkstra et al [11] 2021 Prospective Amsterdam 136 65.1 104:32 29.1
Puijk et al [12] 2022 Prospective Amsterdam 329 65.3 222:107 16.5
Tinguely et al [13] 2022 Prospective Sweden 105 66.8 64:41 1.53 48
McEachron et al [14] 2020 Retrospective USA 36 52 21:15 1.9 28
Hof et al [15] 2016 Retrospective Netherlands 431 62.9 264:167 3.5 38.6
Huang et al [16] 2021 Retrospective China 184 57.4 112:72 51.3
Wang et al [17] 2017 Retrospective China 96 59.5 74:22 4.5
Masuda et al [18] 2018 Retrospective USA and Japan 717 58.5 429:288 3
Knott et al [19] 2021 Prospective USA 57 60 35:22 1.8 49.3
Valls et al [20] 2014 Prospective Spain 59 64.1 41:18 2.3 25.3
De Graaff et al [21] 2024 Retrospective Netherlands 2,008 64.5 1,271:737 76.9
Shady et al [22] 2016 Retrospective USA 162 92:70 55
Lee et al [23] 2022 Retrospective South Korea 92 60.2 63:29 1.4 33

 

↓  Table 2. Characteristics of Each Group
 
Author Year Ablation/resection
Sample size Males/females Age (mean) Hospital length stay (mean, days)
Chiappa et al [10] 2016 80/280 37:43/131:149 58/60 9/8
Dijkstra et al [11] 2021 100/36 79:21/25:11 66.9/63.3 1/5
Tinguely et al [13] 2022 52/53 33:19/31:22 67.5/66 1/7
Huang et al [16] 2021 98/86 56:42/56:30 58.8/55.9 3.5/7
Masuda et al [18] 2018 116/601 74:42/355:245 58.5/58.4
De Graaff et al [21] 2024 1,005/1,003 644:361/627:376 64/65

 

↓  Table 3. Summary of Pooled Analysis
 
Outcomes Effect size CI Heterogeneity I2 P value
CI: confidence interval; OR: odds ratio; RR: relative risk.
Overall survival RR: 0.84 0.54 - 1.30 94% 0.35
Tumor recurrence OR: 1.66 1.06 - 2.62 10% 0.03
Disease-free survival RR: 1.00 0.32 - 3.13 89% 0.99
Complications OR: 0.34 0.09 - 1.21 84% 0.08