World Journal of Oncology, ISSN 1920-4531 print, 1920-454X online, Open Access
Article copyright, the authors; Journal compilation copyright, World J Oncol and Elmer Press Inc
Journal website https://www.wjon.org

Original Article

Volume 15, Number 6, December 2024, pages 922-928

Causal Relationships Between Gut Microbiota, Immune Cell and Pancreatic Cancer: A Two-Step, Two-Sample Mendelian Randomization Study

Figures

Figure 1.
Figure 1. The study design. A two-step Mendelian randomization study of GM on PC mediated by immune cell. IVs: instrumental variables; SNP: single nucleotide polymorphism.
Figure 2.
Figure 2. MR analysis showing the causality of Geminocystis on pancreatic cancer is significant. MR: Mendelian randomization; CI: confidence interval; OR: odds ratio; SNP: single nucleotide polymorphism.
Figure 3.
Figure 3. Leave-one-out plots for MR analyses. (a) The causal effect of GM on PC. (b) The causal effect of immune cell on PC. (c) The causal effect of GM on immune cell. SNPs: single nucleotide polymorphisms; MR: Mendelian randomization; GM: gut microbiota; PC: pancreatic cancer.

Table

Table 1. Mediation Effect of Geminocystis on PC via B-Cell Absolute Count in TBNK Panel
 
Total effect βDirect effect A βDirect effect B βMediation effect βMediated proportion (%)
Total effect: The causal role of GM on PC. Direct effect A: The causal role of GM on immune cell traits. Direct effect B: The causal role of immune cell traits on PC. β(Indirect effect) = β(Direct effect A) × β(Direct effect B). The mediated proportion = β(indirect effect)/β(total effect). GM: gut microbiota; PC: pancreatic cancer.
0.948-0.803-0.1810.14515.321